ANTAGONISTS OF NUCLEIC ACID DERIVATIVES

Antagonists of Nucleic Acid Derivatives

Inhibition of the growth of Lactobadlus casei with folic acid as the nutrilite is a general property of 2,4-diaminopyrimidines, 2-aminopyrimidines, and condensed systems containing these groupings (1). These compounds comprise a spectrum of inhibitors. At one end lie the simpler diaminopyrimidines which are competitive antagonists of folic acid (1, 2). The center may be represented by 2-aminopu...

Antagonists of nucleic acid derivatives. II. Reversal studies with substances structurally related to thymine.

One of the major problems of antimetabolite studies is the evaluation of the rale of “secondary reversing agents” (1). In a system in which there exists a competitive relationship between a metabolite and its antimetabolite, the effect of a secondary reversing agent is to increase the ratio of antimetabolite to metabolite required to produce a given inhibition; the secondary reversing agent can...

Inhibition of Nucleic Acid Synthesis by Folie Acid Antagonists*

Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...

Inhibition of nucleic acid synthesis by folic acid antagonists.

Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...

Lxxiv. the Occurrence of Nucleic Acid Derivatives in Nitrogen-fixing